If you've been doing research on DHEA, you've probably also heard of 7-Keto DHEA. But what is the difference and which one is the right one for you?
7-Keto DHEA is a biologically active metabolite of DHEA that promotes better health and energy without the potential side effects of increased amounts of hormones. 7-Keto DHEA boosts the immune system by increasing the production of certain types of white blood cells; it increases energy and metabolism by activating enzymes in the liver that boost the rate of thermogensis (the process by which fat is burned).
7-Keto has all the non-hormonal effects of DHEA, and may even be more potent in this regard. However 7-Keto will not have some of the effects that DHEA has such as improved libido.
DHEA is the most plentiful hormone in the human body, but its production declines with age. As the levels of DHEA decrease, so does this important metabolite, 7-KETO. The levels of DHEA and its numerous derivatives, manufactured in the adrenal glands, begin to decline after the age of 30 with about a 50% decline by the age of 40 and about 85% decline by the age of 70. As these hormone levels decline during the aging process, there are some detrimental physiological and anatomical effects which occur as a result. These include a reduction in protein biosynthesis which lead to a loss in muscle mass, and reduction in bone tissue regeneration which causes a loss of bone mass (a risk factor for osteoporosis). Other effects include the decline in the metabolic rate which causes an increase in fat accumulation, a decline in various immune system functions, and an increased rate of memory loss.
One of the effects n of 7-KETO in a double blind, placebo controlled human, clinical trial was the stimulation of liver enzymes, which increase heat production using fat as the primary source of energy. Naturally, this resulted in the reduction of adipose fat tissue when combined with exercise. Other clinical studies in humans indicated 7-KETO improved immunity and also memory-related functions. In all cases, 7-KETO was demonstrated to be substantially more effective than DHEA without the sex hormone related, side effects.
The safety evaluation of 7-KETO has been done through observations from an extensive number of pre-clinical and clinical safety studies in both humans and animal subjects. In all cases, 7-KETO was consistently found to be safe for human consumption as a dietary supplement.